To our knowledge, this is the first study that demonstrates a possible relationship between the efficacy of Cialis (tadalafil) and the presence of Cialis-associated symptoms in patients with chronic heart failure.
To investigate the effect of cialis and tadalafil on the prevalence and severity of heart failure-related symptoms in a group of patients with heart failure.
In a retrospective cohort study, we used the same questionnaire as used in the Cialis study (see below).
We included adult patients with acute heart failure (defined as ventricular fibrillation for less than 24 hours). The diagnosis of chronic heart failure was based on the International Classification of Diseases, 9th Revision (ICD-9) 14th Revision. The treatment was administered as a single dose of tadalafil (20 mg daily) and Cialis (Tadalafil) at a dose of 2.5 mg, 5 mg, 10 mg and 20 mg. Patients were followed up for 24 months.
After the first and the second period, patients were followed up every 3 months for the entire period (at least 10 years). We measured heart failure-related symptoms at the end of the first, second and third months. We also measured the prevalence of heart failure-related symptoms among the patients who were followed up (defined as: no symptoms and at least 1 heart failure-related symptom).
We assessed patients' mean age and mean sex, respectively. We assessed the prevalence of heart failure-related symptoms and heart failure-related comorbidities.
We identified 439 patients who met inclusion criteria, of whom 277 (63%) were followed up (median 18 months). Of these, 277 (60%) were diagnosed with chronic heart failure. A significant relationship between treatment and severity of heart failure-related symptoms was observed in patients who were followed up (p<0.001) and those who were not.
Patients with heart failure-related symptoms and heart failure-related comorbidities have been found to be at increased risk for developing chronic heart failure. The relationship between treatment and heart failure-related symptoms is unknown. We conclude that Cialis is a possible treatment for chronic heart failure. Cialis, in particular, is a possible treatment for heart failure-related symptoms. We believe that this may help to improve heart failure patient's quality of life and reduce the burden of heart failure. Further studies are needed to determine the effect of Cialis on the presence of heart failure symptoms.
Citation:Chen L-M, Liu P-M, Wang H-M, Li Y-Y, et al. (2015) The effect of tadalafil on the prevalence and severity of heart failure-related symptoms in a cohort of patients with heart failure. PLoS ONE 9(9): e117701. https://doi.org/10.1371/journal.pone.0144127
Editor:David R. D'Ancona, University of North Texas, UNITED STATES
Received:November 21, 2015;Accepted:March 26, 2016;Published:May 12, 2016
Copyright:© 2016 Chen et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the manuscript and its Supporting Information files.
Funding:This work was supported by grants from the NIH (R01Ayahoo1558), NIH (P01ES015867 and U01gary055971), NIH (CA155887) and the National Institute of Health (CA120817). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
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